Dehydrated human amniotic membrane allograft with chorion

VENDAJE™️ AC is a dehydrated human amnion/chorion membrane allograft with numerous clinical applications. Derived from the placenta, VENDAJE™️ AC retains the full spectrum of growth factors, cytokines, and bioactive extracellular matrix (ECM) scaffolding that support fetal development and regulate fetomaternal immunity. VENDAJE™️ AC also includes Wharton's jelly, which is a connective tissue in the umbilical cord that’s rich in collagen, hyaluronic acid, and growth factors.

VENDAJE™️ AC allografts are aseptically processed and terminally sterilized, making them suitable for topical and intra-operative applications, and they have an ambient shelf life of 3-years. The minimally manipulated, dehydrated membrane provides a natural scaffold for cellular ingrowth with minimal scarring. VENDAJE™️ AC is anti-inflammatory, anti-microbial, and a natural pathogen barrier, resulting in improved clinical outcomes and patient satisfaction.

VENDAJE™ AC is available in 1x1cm, 2x2cm, 2x4cm, 4x4cm, 4x6cm, 4x8cm, and 6x6cm sizes.

The amniotic sac is the inner lining of the placenta, and it supports the fetus throughout development, so it needs to be strong, flexible, and adaptable. It’s made of two distinct but conjoined membranes, the amnion and chorion. The structural integrity of the amniotic and chorionic membranes is due to a complex, bioactive ECM that is composed of collagens, fibronectin, laminin, and proteoglycans, which are integral to tissue regeneration and wound healing1. The ECM also has a high concentration of hyaluronic acid, which promotes non-fibrotic healing and minimizes scarring2.

Multipotent amniotic epithelial and mesenchymal stem cells secrete a broad array of growth factors that support fetal development, including epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), keratinocyte growth factor (KGF), transforming growth factors alpha and beta (TGF‐α and TGF‐β), and nerve growth factor (NGF)3. Used therapeutically, these compounds have powerful healing capabilities even in chronic conditions.

The amniotic and chorionic membranes produce a number of paracrine-acting immunosuppressive cytokines, including interleukins 4 and 10 (IL-4 and IL-10) and prostaglandin E2 (PGE2), which inhibit activation and proliferation of CD4+ and CD8+ T cells and B cells and suppress differentiation of monocytes to antigen-presenting dendritic cells4. Amniotic immunosuppressors also upregulate anti-inflammatory M2 macrophage activation5 and block the release of pro-inflammatory IFN-γ from cytotoxic natural killer (NK) cells6.

The amniotic membranes have a long history in regenerative medicine7, and new applications are identified regularly. Amniotic allografts promote re-epithelialization while minimizing inflammation, making them ideal topical treatments for burns8 (even in pediatric populations9), pressure ulcers10, and other dermal wounds. Chronic conditions like diabetic ulcers are also improved with amniotic allografts11.

VENDAJE™ AC Key Points

  • Bonds with wounds by forming fibrin-elastin at the wound-dressing interface
  • Acts as a vapor barrier, preventing fluid loss from excessive evaporation from the wound surface
  • Designed for application directly to acute and chronic wounds
  • Adheres naturally via hydrostatic tension
  • No blood typing or donor matching required
  • No orientation issues, can be applied on either side
  • Contains full spectrum of growth factors
  • Biocompatible scaffold with extracellular matrix
  • No Immune Rejection
  • Moderate levels of fibronectin and laminin
  • Anti-fibrotic and anti-adhesion barrier
  • High tensile strength

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(954) 380-8342

2836 Center Port Circle
Pompano Beach, FL 33064




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