Flowable Cryopreserved Umbilical Cord and Wharton's Jelly Allograft

OROPRO™ is a cryopreserved human tissue allograft derived from the umbilical cord and the Wharton's jelly. OROPRO™ is aseptically processed to preserve the cytokines, growth factors and proteins present in Wharton's jelly for homologous use. Ourcontrolled-rate freezing process cryopreserves the allografts without significantly affecting viability.
OROPRO™ is intended for the repair, reconstruction, replacement, or supplementation of a recipient’s cells or tissues and to perform the same basic function or functions in the recipient as in the donor. The amount and administration (injected or applied topically) of the allograft is determined by the clinician based on the intended use in each patient case.

Components Present in Umbilical Cord Tissue and Wharton's Jelly

Mesenchymal Stromal Cell (MSCs): Wharton’s jelly mesenchymal stromal cells (WJ-MSCs) are a class of stem cells with high differentiative potential, an immuno-privileged status and easy access for collection, which raise no legal or ethical issues. WJ-MSCs have immunomodulatory properties, involving both innate and adaptive immune responses.1
Bioactive ECM and Growth Factors: Adhesion G protein, Platelet Derived Growth Factor (PDGF), Epidermal Growth Factor (EGF) and Basic Fibroblast Growth Factor (bFGF).
Interleukins: IL-1RA (A natural inhibitor of the pro-inflammatory effect of IL1b), IL-2R (Promotes the differentiation of certain immature T cells into regulatory T cells), IL-4 (Inhibits classical activation of macrophages into M1 cells), and IL-13 (Mediator of allergic inflammation).

OROPRO™ is available in 1.0 and 2.0 mL sizes.

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1. Marino L, Castaldi MA, Rosamilio R, et al. Mesenchymal Stem Cells from the Wharton's Jelly of the Human Umbilical Cord: Biological Properties and Therapeutic Potential. Int J Stem Cells. 2019;12(2):218-226. doi:10.15283/ijsc18034