The Science Behind a Growing Class of Therapies
At BioStem, we develop, manufacture, and market placental tissue products that tap the healing potency of the amniotic membrane. The amniotic environment is rich in growth factors and peptides associated with the generation of new tissue, and because amniotic tissues are also immunologically privileged, they are also highly biocompatible.1-3 This reduces the risk of host rejection reactions that could potentially complicate treatment and produce adverse effects.4,5
The powerful substances found in amniotic tissue have been shown to perform a range of functions in vivo:
- Moderate inflammation4
- Regulate cell migration, proliferation, and metabolism4
- Promote stem cell recruitment4,6
- Reduce scar tissue formation and enhance healing4
- Defend against pathogens through natural antimicrobial activity4,6
Exploring Therapeutic Applications
With the opioid crisis claiming lives every day, it’s more important than ever to provide patients with access to addiction-free options that can safely address sources of pain, provide support during recovery from surgical procedures, and work with bodies to reduce inflammation and tissue degradation in chronic conditions.
Here are a few of the areas where physicians integrate regenerative medicine into their treatment strategies4:
- Diabetic Foot Ulcers and Other Chronic Wounds
- Post-Surgical Healing
- Burn Healing
- Orthopedic Tissue Injuries
- Ophthalmic Tissue Repair
Our placentally-derived products are carefully sourced and manufactured to ensure potency and patient safety:
A connective tissue allograft flowable matrix
A chorion-free, dehydrated amniotic allograft membrane
VENDAJE AC ™
A dehydrated amniotic allograft membrane containing chorion layer and Wharton’s Jelly
VENDAJE OPTIC ™
A dehydrated extracellular amniotic allograft membrane for use as a scaffold for ocular repair
Placentally-derived products come from the placental birth tissue of healthy and rigorously screened donors. These tissues are then processed based on their intended use.
Preserved amniotic membrane does not cause an immune reaction or inflammation in host tissues.3,5 It also contains immunoregulatory factors to further prevent adverse immune reactions. That is why it’s considered immunologically privileged.
Various substances in the amniotic membrane, including growth factors and cytokines, interact to stimulate the body’s stem cells. Once “recruited” through stimulation by these factors, the body’s own stem cells begin to promote tissue healing and repair.6
An allograft is a human tissue graft from a donor that is not genetically identical to the recipient. Allografts are differentiated from organs, which require anti-rejection measures, and autografts, which are made of tissue that comes from elsewhere in the recipient’s body.
The amniotic membrane is made up of two layers: amnion and chorion. The amnion surrounds the fetus, while the chorion is the outer layer that comes into contact with maternal tissue.
Wharton’s Jelly is found in the umbilical cord and contain mesenchymal stroma/stem cells (MSCs) and growth factors that have been shown to have more proliferation and differentiation capabilities than adult stem cells.8
References: 1. Tao H, Fan H. Implantation of amniotic membrane to reduce postlaminectomy epidural adhesions. Eur Spine J. 2009; 18(8):1202-12. 2. Tseng SC, Li DQ, Ma X. Suppression of transforming growth factor-beta isoforms, TGF-beta receptor type II, and myofibroblast differentiation in cultured human corneal and limbal fibroblasts by amniotic membrane matrix. J Cell Physiol. 1999; 179(3):325-35. 3. Hao Y, Ma DH, Hwang DG, Kim WS, Zhang F. Identification of antiangiogenic and anti-inflammatory proteins in human amniotic membrane. Cornea. 2000; 19(3):348-52. 4. Islam R, Rahman S, Asaduzzaman SM, Rahman MS. Properties and Therapeutic Potential of Human Amniotic Membrane. Asian J Dermatol. 2015; 7(1):1-12. 5. Kubo M, Sonoda Y, Muramatsu R, Usui M. Immunogenicity of Human Amniotic Membrane in Experimental Xenotransplantation. Investigative Opth & Vis Sci. 2001; 42(7): 1539-46. 6. Niknejad H, Jorjani M, Ahmadiani A, Ghanavi J, Seifalian A. Properties of the Amniotic Membrane for Potential Use in Tissue Engineering. Eur Cells & Materials. 2008; 15: 88-99. Raines AL, Shih MS, Chua L, Su CW, Tseng SC. O’Connell J. Efficacy of Particulate Amniotic Membrane and Umbilical Cord Tissues in Attenuating Cartilage Destruction in an Osteoarthritis Model. Tissue Engineering Part A. 2017; 23(1-2). 8. Wang HS, Hung SC, Peng ST, Huang CC, Wei HM, Guo YJ, et al. Mesenchymal Stem Cells in the Wharton’s Jelly of the Umbilical Cord. Stem Cells. 2004; 22: 1330-1337.