Regenerative medicine is a relatively new field. Its name was coined in 1999 by William Hasseltine to describe an emerging field that combines tissue engineering, cell transplantation, stem cell biology, biomechanics prosthetics, nanotechnology, and biochemistry.¹
Since then, regenerative medicine has grown exponentially, becoming a cutting-edge field that is changing the way we view bodies. Doctors and scientists use stem cells, gene therapy, and biomedical engineering to regenerate tissue or stimulate cell growth. In 2020, a team of scientists in Italy developed optoceutics, a new technique that uses light to harness the body's ability to heal.²
The history of regenerative medicine is surprisingly long. Regeneration has always been present in nature. Salamanders can regenerate a missing limb in several days, while many invertebrates can even regenerate an entire head from a severed piece of tail.
Scientists started researching regenerative medicine in the early 1900s. In 1968, doctors performed the first bone marrow transplant. By 1981, scientists had developed the world's first in vitro stem cell line in mice. Researchers raced toward cloning, successfully creating Dolly, the first cloned sheep, in 1996.
Later research discovered stem cells derived from amniotic fluid and placenta and allowed solid organ engineering using donated liver tissue.² Today, research institutions like the Mayo Clinic and Istituto Italiano di Tecnologia (IIT) are pushing the field to new heights.
Tissue regeneration is one of the main focuses of regenerative medicine. The field comes up with innovative ways to find tissues capable of regeneration and then determine the best way to stimulate regeneration.
Many current therapies rely on transplantation. However, there is a greater risk of immunological reactions and patients have to take immunosuppressants.³ By stimulating the regeneration of the patient's tissue, blood vessels, or cells, we can lessen the likelihood of organ or tissue rejection.
Nearly 50% of Americans will develop a chronic medical problem in their lifetime. These issues are often caused by catastrophic medical events that leave lasting damage that the body cannot heal on its own. By harnessing the body's regenerative capabilities, doctors can reduce complications from heart attacks, diabetes, or spinal cord injuries.⁴
Regenerative medicine therapies can stimulate the growth of new tissue, cells, or blood vessels throughout the human body. These therapies can give patients relief from chronic pain and issues, and, if effective, lessen their reliance on medications.
Since discovering stem cells in the amniotic fluid and placenta, researchers have created therapies that can help regenerate damaged cells. Stem cells capable of proliferating, differentiating, and replacing damaged host cells or stimulating regeneration effectively answer the lack of organ donors available.⁵
These stem cells can be used in the cardiovascular, gastrointestinal, musculoskeletal, nervous, and respiratory systems, as well as on the skin.
BioStem Technologies has developed RHEO, a connective tissue allograft flowable matrix. This new, less invasive treatment option for patients has anti-inflammatory, anti-microbial, and regenerative properties.
Derived from a combination of chorion-free placental tissue and amniotic fluid, RHEO is cryopreserved to ensure that its properties remain undisturbed until use. Our team carefully monitors the cryopreservation process.
RHEO's use of amniotic fluid increases its useful properties. Amniotic fluid's growth factors and proteins can help improve bone healing and stimulate the regeneration of nervous tissue.
At BioStem Technologies, we offer many products that deliver amniotic cells to your patients. The BioStem Technologies team is always happy to answer your questions about regenerative medicine or any of our products. If you would like to offer more regenerative therapies, call us at (954) 380-8342 or send us a message via our website.
(1) Gianluca Sampogna, Salman Yousuf Guraya, and Antonello Forgione. “Regenerative Medicine: Historical Roots and Potential Strategies in Modern Medicine.” Journal of Microscopy and Ultrastructure. Originally Published By Elsevier, May 18, 2015. https://www.sciencedirect.com/science/article/pii/S2213879X1500053X
(2) Zuzanna Walter. “Optoceutics: A New Regenerative Medicine Technique” A4M Blog, January 31, 2020. https://blog.a4m.com/optoceutics-a-new-regenerative-medicine-technique/
(3) Dame Julia Polak. “Regenerative Medicine. Opportunities and Challenges: a Brief Overview.” Journal of The Royal Society Interface 7, no. suppl_6, (2010). https://doi.org/10.1098/rsif.2010.0362.focus
(4) “Center for Regenerative Medicine - About.” Mayo Clinic. Mayo Clinic, May 18, 2020. https://www.mayo.edu/research/centers-programs/center-regenerative-medicine/about
(5) Mala Srivastava, Neha Ahlawat, and Ankita Srivastava. “Amniotic Fluid Stem Cells: A New Era in Regenerative Medicine.” The Journal of Obstetrics and Gynecology of India 68, no. 1 (2017): 15–19. https://doi.org/10.1007/s13224-017-1034-z