The Benefits of Amniotic Allograft Injections

January 25, 2021
Benefits Amniotic Allograft Biostem Technologies

Amniotic fluid is an essential cornerstone of regenerative medicine. Doctors use it to treat chronic pain, stimulate cell growth, and regenerate tissue. One of the best ways to deliver the amniotic fluid is through amniotic allograft injections.

Although there are risks of immune system reactions, the benefits of amniotic allograft injections are numerous. The injections can help in several areas of medicine, including sports medicine and orthopedics.

What Is an Amniotic Allograft Injection?

Amniotic allograft injections contain amniotic fluid in a cryopreserved form. Injections come in varying doses and can help with chronic pain and heal certain chronic muscle issues.

Since scientists discovered a method to derive stem cells from amniotic tissue in 2007, researchers have found new ways to incorporate these specialized cells into regenerative medicine therapies.¹ Amniotic allograft injections allow a patient to receive a specified, targeted dosage to treat their medical issue and are less invasive than surgeries or transplants.

The amniotic membrane has been used to treat wounds for nearly 100 years because of its low immunogenic, anti-inflammatory, anti-scarring, and wound-healing properties. It is rich in collagen and contains critical growth factors for the healing process.²

Benefits of Amniotic Allograft Injections

Unlike other treatments, amniotic allograft injections are relatively non-invasive, safe, and effective. Instead of requiring a knee-replacement surgery, a patient can simply use amniotic allograft injections to reduce inflammation and promote the surrounding tissues’ regeneration.³

With the development of cryopreservation, the amniotic fluid can be preserved with all its properties intact until the patient is ready for their injection. This process allows for the delivery and storage of injections, meaning a lack of medication will not delay treatment.

Surgeries are invasive and can require lengthy recovery times or even cause debilitating side-effects. Amniotic allograft injections are not entirely risk-free, but surgeries often pose higher risks, including those associated with anesthesia and transplant rejection.

Because the amniotic membrane has low immunogenicity, it is less likely to cause an immune reaction.⁴ Transplants require the patient to take immunosuppressants, which can leave the patient vulnerable to serious illnesses.

Amniotic Allograft Injections biostem technologies


Amniotic allograft injections can treat medical issues throughout the body, including chronic inflammation, joint problems, tendon and cartilage injuries, and osteoarthritis.

  • Treating Plantar Fasciosis and Achilles Tendinosis

Heel pain affects nearly two million Americans. Plantar fasciosis and Achilles tendinosis are two of the most common causes, and current treatments only alleviate the pain rather than treat the underlying issues.⁵

The anti-inflammatory properties of amniotic fluid can help reduce the inflammation causing the pain. In a 2015 study, physicians treated patients with chronic plantar fasciosis or Achilles tendinosis with one amniotic allograft injection in the heel. Within 12 weeks, their self-reported pain level had reduced to 2, and no patients reported adverse reactions.⁶

These findings can likely be applied in other parts of the body with chronic inflammation. Other forms of tendonitis and knee pain caused by inflammation are potential areas for application. Amniotic injections can also help to treat some types of osteoarthritis.

  • Using Amniotic Injections in Sports Medicine

Often, patients seek out sports medicine physicians because of damaged tendons or cartilage that limit their mobility and cause pain. An amniotic injection near the affected cartilage or tendon can stimulate growth factors and encourage the tendon to repair itself.⁷

Amniotic injections in sports medicine are a developing application and require more research before it can be commercially applied.

Rotator Cuff Tears_BioStem technology
  • Rotator Cuff Tears

Rotator cuff injuries can be excruciating and take a long time to heal. The use of amniotic injections to reduce inflammation and promote growth factors can speed up the healing process, similarly to treating chronic tendonitis.⁸

Amniotic fluid is ideal for shoulder injuries because it can increase blood flow, re-organize collagen, and protect cartilage. Treatment of shoulder injuries with amniotic injections is in clinical trials and shows promise.

Amniotic Allograft Injections: Your Options

BioStem Technologies offers amniotic allograft injections. If you require amniotic fluid for your treatment, use BioStem Technologies' RHEO, a connective tissue allograft flowable matrix. RHEO is derived from human placental tissue that is chorion-free and amniotic fluid. Its anti-inflammatory, anti-microbial, and regenerative properties make it ideal for treating chronic pain caused by inflammation or stimulating growth in damaged tendons.

Contact Us

The team at BioStem Technologies is always available to answer any questions about our current projects or the future of regenerative medicine. Call us at (954) 380-8342 to learn more about how you can use regenerative medicine therapies in your practice.


(1) Sampogna, Gianluca, Salman Yousuf Guraya, and Antonello Forgione. “Regenerative Medicine: Historical Roots and Potential Strategies in Modern Medicine,” May 18, 2015.

(2) Ra, Md. Shaifur, Rashedul Islam, S.m. Asaduzzama, and M. Shahedur R. “Properties and Therapeutic Potential of Human Amniotic Membrane.” Asian Journal of Dermatology 7, no. 1 (2015): 1–12.

(3) Romero, Tracey. “Amniotic Fluid Injections to Treat Painful Knees.” Orthopedics This Week, October 9, 2019.  

(4) Islam, Rahman, Asaduzzama, Shahedur. “Properties and Therapeutic Potential of Human Amniotic Membrane,” 2015.

(5) Bruce Werber. “Amniotic Tissues for the Treatment of Chronic Plantar Fasciosis and Achilles Tendinosis.” Journal of Sports Medicine. Hindawi, September 27, 2015. 

(6) Werber, “Amniotic Tissues for the Treatment of Chronic Plantar Fasciosis and Achilles Tendinosis.” September 27, 2015.

(7) Greg Rubin. “Review of Amniotic Fluid Injections.” The Sports Medicine Review. The Sports Medicine Review, November 19, 2019.  

(8) Brent Ponce, MD. “Amnion-Based Injections in the Shoulder ” The University of Alabama at Birmingham, March 6, 2020.  

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